Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis

Lumbar spinal canal stenosis (LSS) or mechanical compression of dorsal root ganglion (DRG) is one of the causes of low back pain and neuropathic pain (NP). Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotaxin (ATX)...

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發表在:Sci Rep
Main Authors: Uranbileg, Baasanjav, Ito, Nobuko, Kurano, Makoto, Kano, Kuniyuki, Uchida, Kanji, Sumitani, Masahiko, Aoki, Junken, Yatomi, Yutaka
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889906/
https://ncbi.nlm.nih.gov/pubmed/33597645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83569-3
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