Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels

Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the potential relevance of ATX and LPA in HCC. Fi...

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Vydáno v:PLoS One
Hlavní autoři: Enooku, Kenichiro, Uranbileg, Baasanjav, Ikeda, Hitoshi, Kurano, Makoto, Sato, Masaya, Kudo, Hiroki, Maki, Harufumi, Koike, Kazuhiko, Hasegawa, Kiyoshi, Kokudo, Norihiro, Yatomi, Yutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008774/
https://ncbi.nlm.nih.gov/pubmed/27583415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161825
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