Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels

Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the potential relevance of ATX and LPA in HCC. Fi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Enooku, Kenichiro, Uranbileg, Baasanjav, Ikeda, Hitoshi, Kurano, Makoto, Sato, Masaya, Kudo, Hiroki, Maki, Harufumi, Koike, Kazuhiko, Hasegawa, Kiyoshi, Kokudo, Norihiro, Yatomi, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008774/
https://ncbi.nlm.nih.gov/pubmed/27583415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161825
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