Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

Osteosarcoma is the most common primary bone malignancy affecting children and adolescents. Although several genetic predisposing conditions have been associated with osteosarcoma, our understanding of its pathobiology is rather limited. Here we show that, first, an imprinting defect at human 14q32-...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Shu, Jingmin, Li, Lihua, Sarver, Anne E., Pope, Emily A., Varshney, Jyotika, Thayanithy, Venugopal, Spector, Logan, Largaespada, David A., Steer, Clifford J., Subramanian, Subbaya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008286/
https://ncbi.nlm.nih.gov/pubmed/26802029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6965
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