Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines

Downregulation of microRNAs (miRNAs) at the 14q32 locus stabilizes the expression of cMYC, thus significantly contributing to osteosarcoma (OS) pathobiology. Here, we show that downregulation of 14q32 miRNAs is epigenetically regulated. The predicted promoter regions of miRNA clusters at 14q32 locus...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Thayanithy, Venugopal, Park, ChangWon, Sarver, Aaron L., Kartha, Reena V., Korpela, Derek M., Graef, Ashley J., Steer, Clifford J., Modiano, Jaime F., Subramanian, Subbaya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434163/
https://ncbi.nlm.nih.gov/pubmed/22957032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043720
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