Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines

Downregulation of microRNAs (miRNAs) at the 14q32 locus stabilizes the expression of cMYC, thus significantly contributing to osteosarcoma (OS) pathobiology. Here, we show that downregulation of 14q32 miRNAs is epigenetically regulated. The predicted promoter regions of miRNA clusters at 14q32 locus...

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Detalhes bibliográficos
Main Authors: Thayanithy, Venugopal, Park, ChangWon, Sarver, Aaron L., Kartha, Reena V., Korpela, Derek M., Graef, Ashley J., Steer, Clifford J., Modiano, Jaime F., Subramanian, Subbaya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434163/
https://ncbi.nlm.nih.gov/pubmed/22957032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043720
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