Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor how they, in turn, regulate it. Herein, we demonstrate that the yeast alkaline ceramidases (YPC1 and YDC1) and SB kinases (LCB4 and LCB5) co...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Yi, Jae Kyo, Xu, Ruijuan, Jeong, Eunmi, Mileva, Izolda, Truman, Jean-Philip, Lin, Chih-li, Wang, Kai, Snider, Justin, Wen, Sally, Obeid, Lina M., Hannun, Yusuf A., Mao, Cungui
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper: Gerotarget (Focus on Aging)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008273/
https://ncbi.nlm.nih.gov/pubmed/27008706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8195
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