Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor how they, in turn, regulate it. Herein, we demonstrate that the yeast alkaline ceramidases (YPC1 and YDC1) and SB kinases (LCB4 and LCB5) co...

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Vydáno v:Oncotarget
Hlavní autoři: Yi, Jae Kyo, Xu, Ruijuan, Jeong, Eunmi, Mileva, Izolda, Truman, Jean-Philip, Lin, Chih-li, Wang, Kai, Snider, Justin, Wen, Sally, Obeid, Lina M., Hannun, Yusuf A., Mao, Cungui
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper: Gerotarget (Focus on Aging)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008273/
https://ncbi.nlm.nih.gov/pubmed/27008706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8195
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