Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function

Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor how they, in turn, regulate it. Herein, we demonstrate that the yeast alkaline ceramidases (YPC1 and YDC1) and SB kinases (LCB4 and LCB5) co...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Yi, Jae Kyo, Xu, Ruijuan, Jeong, Eunmi, Mileva, Izolda, Truman, Jean-Philip, Lin, Chih-li, Wang, Kai, Snider, Justin, Wen, Sally, Obeid, Lina M., Hannun, Yusuf A., Mao, Cungui
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008273/
https://ncbi.nlm.nih.gov/pubmed/27008706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8195
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