Phase I/II Clinical Trial of Hyaluronan-Cisplatin Nanoconjugate for the Treatment of Spontaneous Canine Cancers

OBJECTIVE: To conduct an open label, multi-dose Phase I/II clinical study in spontaneous canine cancers and evaluate the pharmacokinetics, safety, and efficacy of the hyaluronan-based cisplatin formulation (HA-Pt). ANIMALS: 13 dogs with heterogeneous, naturally occurring cancers. PROCEDURES: The dog...

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Veröffentlicht in:Am J Vet Res
Hauptverfasser: Cai, Shuang, Zhang, Ti, Forrest, W.C., Yang, Qiuhong, Groer, Chad, Mohr, Eva, Aires, Daniel J., Axiak-Bechtel, Sandra M., Flesner, Brian K., Henry, Carolyn J., Selting, Kimberly A., Tate, Deborah, Swarz, Jeffrey A., Bryan, Jeffrey N., Forrest, M. Laird
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008241/
https://ncbi.nlm.nih.gov/pubmed/27580113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2460/ajvr.77.9.1005
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