Hyaluronan-lysine cisplatin drug carrier for treatment of localized cancers: pharmacokinetics, tolerability, and efficacy in rodents and canines

The purpose of this study was to develop a safe and efficacious drug delivery platform for sustained release of cisplatin after locoregional administration. We successfully synthesized hyaluronan-cisplatin nanoconjugates (HA-Lys-Pt) using an N-Ac-lysine linker, which formed a thermodynamically stabl...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Zhang, Ti, Cai, Shuang, Groer, Chad, Forrest, W.C., Yang, Qiuhong, Mohr, Eva, Douglas, Justin, Aires, Daniel, Axiak-Bechtel, Sandra M., Selting, Kimberly A., Swarz, Jeffrey A., Tate, Deborah J., Bryan, Jeffrey N., Forrest, M. Laird
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885795/
https://ncbi.nlm.nih.gov/pubmed/27155765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.03.018
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