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Cellular Uptake and Internalization of Hyaluronan-based Doxorubicin and Cisplatin Conjugates

BACKGROUND: Hyaluronan (HA) is a ligand for the CD44 receptor which is crucial to cancer cell proliferation and metastasis. High levels of CD44 expression in many cancers have encouraged the development of HA-based carriers for anti-cancer therapeutics. PURPOSE: The objective of this study was to de...

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Detalhes bibliográficos
Publicado no:J Drug Target
Main Authors: Cai, Shuang, Alhowyan, Adel Ali B, Yang, Qiuhong, Forrest, W.C. Melanie, Shnayder, Yelizaveta, Forrest, M. Laird
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620033/
https://ncbi.nlm.nih.gov/pubmed/24892741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/1061186X.2014.921924
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