Pulmonary delivery of cisplatin-hyaluronan conjugates via endotracheal instillation for the treatment of lung cancer

Cisplatin (CDDP) intravenous treatments suffer several dose-limiting toxicity issues. Hyaluronan (HA), a naturally occurring biopolymer in the interstitium, is primarily cleared by the lymphatic system. An alteration in input rate and administration route through pulmonary delivery of hyaluronan-cis...

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Main Authors: Xie, Yumei, Aillon, Kristin L., Cai, Shuang, Christian, Jason M., Davies, Neal M., Berkland, Cory J., Forrest, M. Laird
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873163/
https://ncbi.nlm.nih.gov/pubmed/20363303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2010.03.058
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