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Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance

Quinolone antimicrobials are widely used in clinical medicine and are the only current class of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase and topoisomerase IV binding to specific domains and conformations so as to block DNA strand passage catalysis and...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Perspect Med
Main Authors: Hooper, David C., Jacoby, George A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008060/
https://ncbi.nlm.nih.gov/pubmed/27449972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a025320
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