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Interaction of the Plasmid-Encoded Quinolone Resistance Protein QnrA with Escherichia coli Topoisomerase IV

Purified QnrA blocked ciprofloxacin inhibition of topoisomerase IV, just as QnrA was previously found to prevent quinolone inhibition of DNA gyrase. With a gel displacement assay, tagged QnrA was shown to bind to topoisomerase IV and its subunits in a reaction that did not depend on the presence of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tran, John H., Jacoby, George A., Hooper, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168640/
https://ncbi.nlm.nih.gov/pubmed/15980397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.3050-3052.2005
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