Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure

Although numerous functions of inositol-requiring enzyme 1α (IRE1α) have been identified, a role of IRE1α in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown. Here, we showed that mice lacking IRE1α specifically in POMC neurons (PIKO) are lean and res...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Open Biol
Prif Awduron: Xiao, Yuzhong, Xia, Tingting, Yu, Junjie, Deng, Yalan, Liu, Hao, Liu, Bin, Chen, Shanghai, Liu, Yong, Guo, Feifan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008012/
https://ncbi.nlm.nih.gov/pubmed/27558934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160131
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