Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure

Although numerous functions of inositol-requiring enzyme 1α (IRE1α) have been identified, a role of IRE1α in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown. Here, we showed that mice lacking IRE1α specifically in POMC neurons (PIKO) are lean and res...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Xiao, Yuzhong, Xia, Tingting, Yu, Junjie, Deng, Yalan, Liu, Hao, Liu, Bin, Chen, Shanghai, Liu, Yong, Guo, Feifan
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008012/
https://ncbi.nlm.nih.gov/pubmed/27558934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160131
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