Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

Acute myeloid leukemia (AML) is associated with poor natural killer (NK) cell function through aberrant expression of NK-cell-activating receptors and their ligands on tumor cells. These alterations are thought to promote formation of inhibitory NK-target cell synapses, in which killer cell degranul...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Kearney, Conor J., Ramsbottom, Kelly M., Voskoboinik, Ilia, Darcy, Phillip K., Oliaro, Jane
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007960/
https://ncbi.nlm.nih.gov/pubmed/27622064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1196308
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