Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Failure of cytotoxic T lymphocytes (CTLs) or natural killer (NK) cells to kill target cells by perforin (Prf)/granzyme (Gzm)-induced apoptosis causes severe immune dysregulation. In familial hemophagocytic lymphohistiocytosis, Prf-deficient infants suffer a fatal “cytokine storm” resulting from macr...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Jenkins, Misty R., Rudd-Schmidt, Jesse A., Lopez, Jamie A., Ramsbottom, Kelly M., Mannering, Stuart I., Andrews, Daniel M., Voskoboinik, Ilia, Trapani, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354371/
https://ncbi.nlm.nih.gov/pubmed/25732304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140964
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