The BET-bromodomain inhibitor JQ1 renders neuroblastoma cells more resistant to NK cell-mediated recognition and killing by downregulating ligands for NKG2D and DNAM-1 receptors

Low expression of ligands for NK cell-activating receptors contributes to neuroblastoma (NB) aggressiveness. Recently, we demonstrated that the expression of MYCN, a poor prognosis marker in NB, inversely correlates with that of activating ligands. This indicates that MYCN expression level can predi...

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Foilsithe in:Oncotarget
Main Authors: Veneziani, Irene, Fruci, Doriana, Compagnone, Mirco, Pistoia, Vito, Rossi, Paolo, Cifaldi, Loredana
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2019
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481332/
https://ncbi.nlm.nih.gov/pubmed/31040907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26736
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