The tumour suppressor CYLD regulates the p53 DNA damage response

The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-κB, MAP kinase and Wnt signalling. However, the tumour suppressing mechanisms of CYLD remain poorly understood. Here we show that loss of CYLD catalytic activity causes impaired DNA damage-induced p53 stabilization and act...

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Publicado no:Nat Commun
Main Authors: Fernández-Majada, Vanesa, Welz, Patrick-Simon, Ermolaeva, Maria A., Schell, Michael, Adam, Alexander, Dietlein, Felix, Komander, David, Büttner, Reinhard, Thomas, Roman K., Schumacher, Björn, Pasparakis, Manolis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007442/
https://ncbi.nlm.nih.gov/pubmed/27561390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12508
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