Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma

Genotoxic cancer therapies, such as chemoradiation, cause haematological toxicity primarily by activating the tumour suppressor p53. While inhibiting p53-mediated cell death during cancer therapy ameliorates haematologic toxicity, whether it also impacts carcinogenesis remains unclear. Here we utili...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lee, Chang-Lung, Castle, Katherine D., Moding, Everett J., Blum, Jordan M., Williams, Nerissa, Luo, Lixia, Ma, Yan, Borst, Luke B., Kim, Yongbaek, Kirsch, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586051/
https://ncbi.nlm.nih.gov/pubmed/26399548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9477
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