An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer

The tumor suppressor p53 blocks tumor progression in multiple tumor types. Radiation-induced cancer following exposure to radiation therapy or space travel may also be regulated by p53 because p53 has been proposed to respond to DNA damage to suppress tumorigenesis. Here, we investigate the role of...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Moding, Everett J., Min, Hooney D., Castle, Katherine D., Ali, Moiez, Woodlief, Loretta, Williams, Nerissa, Ma, Yan, Kim, Yongbaek, Lee, Chang-Lung, Kirsch, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955525/
https://ncbi.nlm.nih.gov/pubmed/27453951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86698
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