YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

BACKGROUND & AIMS: Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)—a precursor of pancreatic intraepithelial neoplasia...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Gruber, Ralph, Panayiotou, Richard, Nye, Emma, Spencer-Dene, Bradley, Stamp, Gordon, Behrens, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: W.B. Saunders 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007286/
https://ncbi.nlm.nih.gov/pubmed/27215660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2016.05.006
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