Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on cell of origin....

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ferreira, Rute M.M., Sancho, Rocio, Messal, Hendrik A., Nye, Emma, Spencer-Dene, Bradley, Stone, Richard K., Stamp, Gordon, Rosewell, Ian, Quaglia, Alberto, Behrens, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668631/
https://ncbi.nlm.nih.gov/pubmed/29069604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.093
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