Integrin signalling regulates YAP and TAZ to control skin homeostasis

The skin is a squamous epithelium that is continuously renewed by a population of basal layer stem/progenitor cells and can heal wounds. Here, we show that the transcription regulators YAP and TAZ localise to the nucleus in the basal layer of skin and are elevated upon wound healing. Skin-specific d...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Elbediwy, Ahmed, Vincent-Mistiaen, Zoé I., Spencer-Dene, Bradley, Stone, Richard K., Boeing, Stefan, Wculek, Stefanie K., Cordero, Julia, Tan, Ee H., Ridgway, Rachel, Brunton, Val G., Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J., Thompson, Barry J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Stem Cells and Regeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874484/
https://ncbi.nlm.nih.gov/pubmed/26989177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.133728
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