Integrin signalling regulates YAP and TAZ to control skin homeostasis

The skin is a squamous epithelium that is continuously renewed by a population of basal layer stem/progenitor cells and can heal wounds. Here, we show that the transcription regulators YAP and TAZ localise to the nucleus in the basal layer of skin and are elevated upon wound healing. Skin-specific d...

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Veröffentlicht in:Development
Hauptverfasser: Elbediwy, Ahmed, Vincent-Mistiaen, Zoé I., Spencer-Dene, Bradley, Stone, Richard K., Boeing, Stefan, Wculek, Stefanie K., Cordero, Julia, Tan, Ee H., Ridgway, Rachel, Brunton, Val G., Sahai, Erik, Gerhardt, Holger, Behrens, Axel, Malanchi, Ilaria, Sansom, Owen J., Thompson, Barry J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2016
Schlagworte:
Stem Cells and Regeneration
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874484/
https://ncbi.nlm.nih.gov/pubmed/26989177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.133728
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