Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.

Thymocytes from DO10 T-cell-receptor transgenic mice undergo apoptosis, or programmed cell death, when chicken ovalbumin-(323-339) peptide is administered in vivo. Using DO10 mice thymocytes, we have now developed a simple in vitro model system that recapitulates the in vivo clonal-deletion process....

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Main Authors: Iwabuchi, K, Nakayama, K, McCoy, R L, Wang, F, Nishimura, T, Habu, S, Murphy, K M, Loh, D Y
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC50052/
https://ncbi.nlm.nih.gov/pubmed/1409596
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