Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death

Exposure to aminoglycoside antibiotics can lead to the generation of toxic levels of reactive oxygen species (ROS) within mechanosensory hair cells of the inner ear that have been implicated in hearing and balance disorders. Better understanding of the origin of aminoglycoside-induced ROS could focu...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Esterberg, Robert, Linbo, Tor, Pickett, Sarah B., Wu, Patricia, Ou, Henry C., Rubel, Edwin W., Raible, David W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004972/
https://ncbi.nlm.nih.gov/pubmed/27500493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84939
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