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Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death

Exposure to aminoglycoside antibiotics can lead to the generation of toxic levels of reactive oxygen species (ROS) within mechanosensory hair cells of the inner ear that have been implicated in hearing and balance disorders. Better understanding of the origin of aminoglycoside-induced ROS could focu...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Esterberg, Robert, Linbo, Tor, Pickett, Sarah B., Wu, Patricia, Ou, Henry C., Rubel, Edwin W., Raible, David W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004972/
https://ncbi.nlm.nih.gov/pubmed/27500493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84939
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