Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death

Exposure to aminoglycoside antibiotics can lead to the generation of toxic levels of reactive oxygen species (ROS) within mechanosensory hair cells of the inner ear that have been implicated in hearing and balance disorders. Better understanding of the origin of aminoglycoside-induced ROS could focu...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Esterberg, Robert, Linbo, Tor, Pickett, Sarah B., Wu, Patricia, Ou, Henry C., Rubel, Edwin W., Raible, David W.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004972/
https://ncbi.nlm.nih.gov/pubmed/27500493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84939
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