Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells

Aminoglycosides (AGs) are broad-spectrum antibiotics that are associated with kidney damage, balance disorders, and permanent hearing loss. This damage occurs primarily by killing of proximal tubule kidney cells and mechanosensory hair cells, though the mechanisms underlying cell death are not clear...

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Pubblicato in:J Clin Invest
Autori principali: Hailey, Dale W., Esterberg, Robert, Linbo, Tor H., Rubel, Edwin W., Raible, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272180/
https://ncbi.nlm.nih.gov/pubmed/27991862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85052
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