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Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells

Mitochondria play a prominent role in mechanosensory hair cell damage and death. Although hair cells are thought to be energetically demanding cells, how mitochondria respond to these demands and how this might relate to cell death is largely unexplored. Using genetically encoded indicators, we foun...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Pickett, Sarah B, Thomas, Eric D, Sebe, Joy Y, Linbo, Tor, Esterberg, Robert, Hailey, Dale W, Raible, David W
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345563/
https://ncbi.nlm.nih.gov/pubmed/30596476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38062
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