Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance

Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutrophil serine proteases proteinase 3, neutrophil elastase and cathepsin G are able to process t...

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Publicat a:Mol Med
Autors principals: Toonen, Erik JM, Mirea, Andreea-Manuela, Tack, Cees J, Stienstra, Rinke, Ballak, Dov B, van Diepen, Janna A, Hijmans, Anneke, Chavakis, Triantafyllos, Dokter, Wim H, Pham, Christine TN, Netea, Mihai G, Dinarello, Charles A, Joosten, Leo AB
Format: Artigo
Idioma:Inglês
Publicat: Feinstein Institute for Medical Research 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004724/
https://ncbi.nlm.nih.gov/pubmed/27261776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00033
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