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Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids
Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but interaction of bulk anionic phospholipid (PL(−)) wit...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5004336/ https://ncbi.nlm.nih.gov/pubmed/27527100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611616 |
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