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Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels
Inwardly rectifying potassium (Kir) channels regulate multiple tissues. All Kir channels require interaction of phosphatidyl-4,5-bisphosphate (PIP(2)) at a crystallographically identified binding site, but an additional nonspecific secondary anionic phospholipid (PL(−)) is required to generate high...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3868208/ https://ncbi.nlm.nih.gov/pubmed/24270915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3786 |
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