Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer

Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood. Here, we perform an integrative analysis of the structural, interactomic, and regulatory properties of thousands of p...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Latysheva, Natasha S., Oates, Matt E., Maddox, Louis, Flock, Tilman, Gough, Julian, Buljan, Marija, Weatheritt, Robert J., Babu, M. Madan
Format: Artigo
Language:Inglês
Published: Cell Press 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003813/
https://ncbi.nlm.nih.gov/pubmed/27540857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.07.008
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