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Structural design of engineered costimulation determines tumor rejection kinetics and persistence of CAR T cells
T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The costimulatory properties of second-generation chimeric antigen receptors (CARs) determine the overall potency of adoptively transferred T cells. Utilizing an in vivo “stress test” to challenge CD19-targeted T cells, w...
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| Pubblicato in: | Cancer Cell |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003056/ https://ncbi.nlm.nih.gov/pubmed/26461090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.09.004 |
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