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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
Current T cell engineering approaches redirect patient T cells to tumors by transducing antigen–specific T cell receptors (TCRs) or chimeric antigen receptors (CARs) that target a single antigen.(1–3) However, few tumor-specific antigens have been identified, and healthy tissues that express the tar...
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| Veröffentlicht in: | Nat Biotechnol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5505184/ https://ncbi.nlm.nih.gov/pubmed/23242161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2459 |
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