Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

Autophagy degrades and is thought to recycle proteins, other macromolecules, and organelles. In genetically engineered mouse models (GEMMs) for Kras-driven lung cancer, autophagy prevents the accumulation of defective mitochondria and promotes malignancy. Autophagy-deficient tumor-derived cell lines...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Guo, Jessie Yanxiang, Teng, Xin, Laddha, Saurabh V., Ma, Sirui, Van Nostrand, Stephen C., Yang, Yang, Khor, Sinan, Chan, Chang S., Rabinowitz, Joshua D., White, Eileen
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002976/
https://ncbi.nlm.nih.gov/pubmed/27516533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283416.116
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