A novel TP53-KPNA3 translocation defines a de novo treatment-resistant clone in osteosarcoma

Osteosarcoma is the most common primary bone cancer. It can be cured by aggressive surgery and chemotherapy, but outcomes for metastatic or chemoresistant disease remain dismal. Cancer sequencing studies have shown that the p53 pathway is dysregulated in nearly every case, often by translocation; ho...

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Detalles Bibliográficos
Publicado en:Cold Spring Harb Mol Case Stud
Autores principales: Chen, Kenneth S., Kwon, Woo Sun, Kim, Jiwoong, Heo, Su Jin, Kim, Hyo Song, Kim, Hyo Ki, Kim, Soo Hee, Lee, Won Suk, Chung, Hyun Cheol, Rha, Sun Young, Hwang, Tae Hyun
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002927/
https://ncbi.nlm.nih.gov/pubmed/27626065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a000992
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