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Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging

Chronic cardiac hypertrophy is maladaptive and contributes to the pathogenesis of heart failure. The objective of this study was to identify small molecule inhibitors of pathological cardiomyocyte hypertrophy. High content screening was performed with primary neonatal rat ventricular myocytes (NRVMs...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Reid, Brian G., Stratton, Matthew S., Bowers, Samantha, Cavasin, Maria A., Demos-Davies, Kimberley M., Susano, Isidro, McKinsey, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002372/
https://ncbi.nlm.nih.gov/pubmed/27130278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.04.015
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