Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition

BACKGROUND: Patients with pulmonary arterial hypertension (PAH) are treated with vasodilators, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 (PDE-5) inhibitors, soluble guanylyl cyclase activators, and prostacyclin. Despite recent advances in pharmacotherapy for individuals w...

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Pubblicato in:J Transl Med
Autori principali: Cavasin, Maria A, Demos-Davies, Kimberly M, Schuetze, Katherine B, Blakeslee, Weston W, Stratton, Matthew S, Tuder, Rubin M, McKinsey, Timothy A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255666/
https://ncbi.nlm.nih.gov/pubmed/25425003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0314-y
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