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Inhibition of G protein βγ subunit signaling abrogates nephritis in lupus prone mice

OBJECTIVE: Despite considerable advances in the understanding of systemic lupus erythematosus (SLE), there is still an urgent need for new and more targeted treatment approaches. We previously demonstrated that small molecule-blockade of Gβγ signaling inhibits acute inflammation through inhibition o...

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Publicat a:Arthritis Rheumatol
Autors principals: Rangel-Moreno, Javier, To, Jesi Y., Owen, Teresa, Goldman, Bruce I., Smrcka, Alan V., Anolik, Jennifer H.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001921/
https://ncbi.nlm.nih.gov/pubmed/26990948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39673
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