Rational engineering of the Neurospora VS ribozyme to allow substrate recognition via different kissing-loop interactions

The Neurospora VS ribozyme is a catalytic RNA that has the unique ability to specifically recognize and cleave a stem-loop substrate through formation of a highly stable kissing-loop interaction (KLI). In order to explore the engineering potential of the VS ribozyme to cleave alternate substrates, w...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Lacroix-Labonté, Julie, Girard, Nicolas, Dagenais, Pierre, Legault, Pascale
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001590/
https://ncbi.nlm.nih.gov/pubmed/27166370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw401
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