Highly selective dopamine D(3) receptor (D(3)R) antagonists and partial agonists based on eticlopride and the D(3)R crystal structure: new leads for opioid dependence treatment

The recent and precipitous increase in opioid analgesic abuse and overdose has inspired investigation of the dopamine D(3) receptor (D(3)R) as a target for therapeutic intervention. Metabolic instability or predicted toxicity has precluded successful translation of previously reported D(3)R-selectiv...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Kumar, Vivek, Bonifazi, Alessandro, Ellenberger, Michael P., Keck, Thomas M., Pommier, Elie, Rais, Rana, Slusher, Barbara S., Gardner, Eliot, You, Zhi-Bing, Xi, Zheng-Xiong, Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001167/
https://ncbi.nlm.nih.gov/pubmed/27508895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00860
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