Dopamine D(3)R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

Prescription opioids such as oxycodone are highly effective analgesics for clinical pain management, but their misuse and abuse have led to the current opioid epidemic in the United States. In order to ameliorate this public health crisis, the development of effective pharmacotherapies for the preve...

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Publicado en:Neuropsychopharmacology
Main Authors: You, Zhi-Bing, Bi, Guo-Hua, Galaj, Ewa, Kumar, Vivek, Cao, Jianjing, Gadiano, Alexandra, Rais, Rana, Slusher, Barbara S., Gardner, Eliot L., Xi, Zheng-Xiong, Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado: Springer International Publishing 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785005/
https://ncbi.nlm.nih.gov/pubmed/30555159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0284-5
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