Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still r...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Nakazawa, Seshiru, Oikawa, Daisuke, Ishii, Ryohei, Ayaki, Takashi, Takahashi, Hirotaka, Takeda, Hiroyuki, Ishitani, Ryuichiro, Kamei, Kiyoko, Takeyoshi, Izumi, Kawakami, Hideshi, Iwai, Kazuhiro, Hatada, Izuho, Sawasaki, Tatsuya, Ito, Hidefumi, Nureki, Osamu, Tokunaga, Fuminori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999505/
https://ncbi.nlm.nih.gov/pubmed/27552911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12547
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