Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

LUBAC (linear ubiquitin chain assembly complex) activates the canonical NF-κB pathway through linear polyubiquitination of NEMO (NF-κB essential modulator, also known as IKKγ) and RIP1. However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20 suppr...

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Hlavní autoři: Tokunaga, Fuminori, Nishimasu, Hiroshi, Ishitani, Ryuichiro, Goto, Eiji, Noguchi, Takuya, Mio, Kazuhiro, Kamei, Kiyoko, Ma, Averil, Iwai, Kazuhiro, Nureki, Osamu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463848/
https://ncbi.nlm.nih.gov/pubmed/23032187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.241
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