Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates

Despite recent technological advances in quantifying antibody drug conjugate (ADC) species, such as total antibody, conjugated antibody, conjugated drug, and payload drug in circulation, the correlation of their exposures with the efficacy of ADC outcomes in vivo remains challenging. Here, the chemi...

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Publicat a:Drug Metab Dispos
Autors principals: Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S., Pillow, Thomas H., Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D., Erickson, Hans K., Hop, Cornelis E. C. A., Khojasteh, S. Cyrus
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2016
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998580/
https://ncbi.nlm.nih.gov/pubmed/27417182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070631
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