Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD(+)-dependent deacetylase. We report that CR reduces nuclear NAD(+) levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Science
Main Authors: Anderson, Rozalyn M., Latorre-Esteves, Magda, Neves, Ana Rute, Lavu, Siva, Medvedik, Oliver, Taylor, Christopher, Howitz, Konrad T., Santos, Helena, Sinclair, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998187/
https://ncbi.nlm.nih.gov/pubmed/14605207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1088697
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker