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Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation
Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD(+)-dependent deacetylase. We report that CR reduces nuclear NAD(+) levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4998187/ https://ncbi.nlm.nih.gov/pubmed/14605207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1088697 |
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