Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD(+)-dependent deacetylase. We report that CR reduces nuclear NAD(+) levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected...

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Publicado en:Science
Autores principales: Anderson, Rozalyn M., Latorre-Esteves, Magda, Neves, Ana Rute, Lavu, Siva, Medvedik, Oliver, Taylor, Christopher, Howitz, Konrad T., Santos, Helena, Sinclair, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2003
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998187/
https://ncbi.nlm.nih.gov/pubmed/14605207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1088697
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