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Amino Acids, Independent of Insulin, Attenuate Skeletal Muscle Autophagy in Neonatal Pigs during Endotoxemia

BACKGROUND: Sepsis induces loss of skeletal muscle mass by activating the ubiquitin proteasome (UPS) and autophagy systems. Although muscle protein synthesis in healthy neonatal piglets is responsive to amino acid (AA) stimulation, it is not known if amino acids (AA) can prevent the activation of mu...

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Bibliographic Details
Published in:Pediatr Res
Main Authors: Hernandez-García, Adriana, Manjarín, Rodrigo, Suryawan, Agus, Nguyen, Hanh V., Davis, Teresa A., Orellana, Renán A.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996682/
https://ncbi.nlm.nih.gov/pubmed/27064245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2016.83
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