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Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia

Sepsis disrupts skeletal muscle proteostasis and mitigates the anabolic response to leucine (Leu) in muscle of mature animals. We have shown that Leu stimulates muscle protein synthesis (PS) in healthy neonatal piglets. To determine if supplemental Leu can stimulate PS and reduce protein degradation...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Hernandez-García, Adriana D., Columbus, Daniel A., Manjarín, Rodrigo, Nguyen, Hanh V., Suryawan, Agus, Orellana, Renán A., Davis, Teresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241557/
https://ncbi.nlm.nih.gov/pubmed/27624100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00217.2016
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